Arizona Cardinals at San Francisco 49ers (September 21, 2025)

Game Recap

Week 3 of the 2025 season saw the San Francisco 49ers defeat the Arizona Cardinals 16-15.

Notes

• Score: San Francisco 49ersSFO defeat Arizona CardinalsARI 16-15
• Date: Sunday, September 21, 2025
• Game Time Kickoff: 4:25PM
• San Francisco 49ers Stats - Yards: 355, Turnovers: 1
• Arizona Cardinals Stats - Yards: 260, Turnovers: 0
• Game Odds:
• -- Line Point Spread: SFO by 1.5
• -- Over/Under: 44.5

Box Score

	1st	2nd	3rd	4th	TOT
ARI	0	3	3	9	15
SFO	0	6	0	10	16

Passing Leaders

PLAYER		C-A	YDS	TD	INT	LNG
Mac Jones	SFO	27-41	284	1	1	34
Kyler Murray	ARI	22-35	159	1	0	32

Rushing Leaders

PLAYER		ATT	YDS	TD	LNG
Christian McCaffrey	SFO	17	52	0	15
Trey Benson	ARI	10	42	0	29
Kyler Murray	ARI	6	37	0	9
Brian Robinson Jr.	SFO	2	22	0	19
James Conner	ARI	9	22	0	9
Greg Dortch	ARI	1	5	0	5
Emari Demercado	ARI	2	0	0	1

Receiving Leaders

PLAYER		REC	YDS	TD	LNG
Ricky Pearsall	SFO	8	117	0	34
Christian McCaffrey	SFO	10	88	0	20
Marvin Harrison Jr.	ARI	3	44	0	32
Trey McBride	ARI	5	43	1	17
Kendrick Bourne	SFO	4	38	0	11
Zay Jones	ARI	2	25	0	18
Jake Tonges	SFO	2	21	0	11
James Conner	ARI	3	15	0	10

Team Total Rushing

TM	ATT	YDS	TD
ARI	28	106	0
SFO	20	73	0

Team Total Passing

TM	C-A	YDS	TD	INT	SCK
ARI	22-35	159	1	0	1
SFO	27-41	284	1	1	1

More Game Information On The Arizona Cardinals at San Francisco 49ers

• Attendance: 70,414
• Weather: 72 degrees, relative humidity 65%, wind 7 mph
• Time of Game: 2:55 - 2 hours, 55 minutes